Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Published:1999-02 Issue:2 Volume:21 Page:230-235
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Terauchi Yasuo,Tsuji Youki,Satoh Shinobu,Minoura Hideaki,Murakami Koji,Okuno Akira,Inukai Kouichi,Asano Tomoichiro,Kaburagi Yasushi,Ueki Kohjiro,Nakajima Hiromu,Hanafusa Toshiaki,Matsuzawa Yuji,Sekihara Hisahiko,Yin Yuxin,Barrett J. Carl,Oda Hideaki,Ishikawa Takatoshi,Akanuma Yasuo,Komuro Issei,Suzuki Misao,Yamamura Ken-ichi,Kodama Tatsuhiko,Suzuki Harumi,Koyasu Shigeo,Aizawa Shinichi,Tobe Kazuyuki,Fukui Yasuhisa,Yazaki Yoshio,Kadowaki Takashi

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng0299_230.pdf

Reference28 articles.

1. Carpenter, C.L. & Cantley, L.C. Phosphoinositide kinases. Curr. Opin. Cell Biol. 8, 153– 158 (1996).

2. Holman, G.D. & Kasaga, M. From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40, 991–1003 (1997).

3. Escobedo, J.A. et al. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3–kinase to the PDGF β–receptor. Cell 65, 75–82 (1991).

4. Otsu, M. et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle–T/pp60c–src complexs, and PI3–kinase. Cell 65, 91– 104 (1991).

5. Skolnik, E.Y. et al. Cloning of PI3 kinase–associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65, 83–90 (1991).

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