Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation-Reference-Cited by-同舟云学术

Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation

Published:2024-01-16 Issue:1 Volume:2 Page:
ISSN:2948-1767
Container-title:npj Viruses
language:en
Short-container-title:npj Viruses

Author:

Port Julia R.,Yinda Claude Kwe,Ruckel Claire,Schulz Jonathan E.,Smith Brian J.,Shaia Carl I.,Munster Vincent J.

Abstract

AbstractThe Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.

Funder

Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s44298-023-00012-2.pdf

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