Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin

Author:

Gaire JanakORCID,Varholick Justin A.ORCID,Rana SabhyaORCID,Sunshine Michael D.ORCID,Doré Sylvain,Barbazuk W. Brad,Fuller David D.ORCID,Maden MalcolmORCID,Simmons Chelsey S.ORCID

Abstract

AbstractThe spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Developmental Biology,Biomedical Engineering,Medicine (miscellaneous)

Reference54 articles.

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3. Seifert, A. W. et al. Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature 489, 561–565 (2012).

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5. Brant, J. O., Yoon, J. H., Polvadore, T., Barbazuk, W. B. & Maden, M. Cellular events during scar-free skin regeneration in the spiny mouse, Acomys. Wound Repair Regen. 24, 75–88 (2016).

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