Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss-Reference-Cited by-同舟云学术

Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Published:2022-10-20 Issue:1 Volume:7 Page:
ISSN:2057-3995
Container-title:npj Regenerative Medicine
language:en
Short-container-title:npj Regen Med

Author:

Clark Andrew,Ghatak Subhadip,Guda Poornachander Reddy,El Masry Mohamed S.^ORCID,Xuan Yi^ORCID,Sato Amy Y.^ORCID,Bellido Teresita,Sen Chandan K.^ORCID

Abstract

AbstractThis work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.

Funder

U.S. Department of Defense

Lilly Endowment INCITE (Indiana Collaborative Initiative for Talent Enrichment) program

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Developmental Biology,Biomedical Engineering,Medicine (miscellaneous)

Link

https://www.nature.com/articles/s41536-022-00259-y.pdf

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