The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis-Reference-Cited by-同舟云学术

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The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis

Published:2015-10-05 Issue:1 Volume:1 Page:
ISSN:2058-7716
Container-title:Cell Death Discovery
language:en
Short-container-title:Cell Death Discovery

Author:

Wolenski F S,Fisher C D,Sano T,Wyllie S D,Cicia L A,Gallacher M J,Baker R A,Kirby P J,Senn J J

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/cddiscovery201534.pdf

Reference46 articles.

1. Roth RA, Luyendyk JP, Maddox JF, Ganey PE . Inflammation and drug idiosyncrasy--is there a connection? J Pharmacol Exp Ther 2003; 307: 1–8.

2. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS et al. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol 2009; 237: 317–330.

3. Beggs KM, Fullerton AM, Miyakawa K, Ganey PE, Roth RA . Molecular mechanisms of hepatocellular apoptosis induced by trovafloxacin-tumor necrosis factor-alpha interaction. Toxicol Sci 2014; 137: 91–101.

4. Liguori MJ, Ditewig AC, Maddox JF, Luyendyk JP, Lehman-McKeeman LD, Nelson DM et al. Comparison of TNFalpha to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: trovafloxacin as an example. Int J Mol Sci 2010; 11: 4697–4714.

5. Swords RT, Erba HP, DeAngelo DJ, Bixby DL, Altman JK, Maris M et al. Pevonedistat (MLN4924), a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study. Br J Haematol 2015; 169: 534–543.

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