Inhibitory Activity of the Hypoxia-inducible Factor-1 Pathway by Tartrolone C-Reference-Cited by-同舟云学术

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Inhibitory Activity of the Hypoxia-inducible Factor-1 Pathway by Tartrolone C

Published:2006-11 Issue:11 Volume:59 Page:693-697
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Yamazaki Yohko,Someno Tetsuya,Minamiguchi Kazuhisa,Kawada Manabu,Momose Isao,Kinoshita Naoko,Doi Hiroyasu,Ikeda Daishiro

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

http://www.nature.com/articles/ja200692.pdf

Reference14 articles.

1. Shweiki D, Itin A, Soffer D, Keshet E . Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843–845 ( 1992)

2. Brown JM, Wilson WR . Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 3: 437–447 ( 2004)

3. Wang GL, Jiang BH, Rue EA, Semenza GL . Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510–5514 ( 1995)

4. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr . HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464–468 ( 2001)

5. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim Av, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ . Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468–472 ( 2001)

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