Production of Ansamycin Polyketide Precursors in Escherichia coli
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
http://www.nature.com/articles/ja200665.pdf
Reference17 articles.
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2. Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C . Biosynthesis of complex polyketides in a metabolically engineered strain of E-coli. Science 291: 1790–1792 ( 2001)
3. Prelog V, Oppolzer W . Ansamycins, new class of microbial metabolites. Helv Chim Acta 56: 2279–2287 ( 1973)
4. Stratmann A, Toupet C, Schilling W, Traber R, Oberer L, Schupp T . Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene. Microbiology 145: 3365–3375 ( 1999)
5. Floss HG, Yu TW . Lessons from the rifamycin biosynthetic gene cluster. Curr Opin Chem Biol 3: 592–597 ( 1999)
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