BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

Author:

Petrij-Bosch Anne,Peelen Tamara,van Vliet Margreethe,Eijk Ronald van,Olmer Renske,Drüsedau Marion,Hogervorst Frans B.L.,Hageman Sandra,Arts Petronella J.W.,Ligtenberg Marjolijn J.L.,Meijers-Heijboer Hanne,Klijn Jan G.M.,Vasen Hans R.A.,Cornelisse Cees J.,van't Veer Laura J.,Bakker Egbert,van Ommen Gert-Jan B.,Devilee Peter

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference25 articles.

1. Couch, F.J. et al. Mutations and polymorphisms in the familial early onset breast cancer (BRCA1). gene. Hum. Mutat. 8, 8–18 (1996).

2. Roa, B.B., Boyd, A.A., Volcik, K. & Richards, C.S., Jewish population frequencies for common mutations in BRCA1 and BRCA2. Nature Genet. 14, 185–187 (1996).

3. Caligo, M.A. et al. BRCA1 germline mutational spectrum in Italian families from Tuscany: a high frequency of novel mutations. Oncogene. 13, 1483–1488 (1996).

4. Peelen, T. et al. A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families. Am. J. Hum. Genet. 60, 1041–1049 (1997).

5. Neuhausen, S.L. et al. Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study. Am. J. Hum. Genet. 58, 271–280 (1996).

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