Orally administered moxifloxacin prolongs QTc in healthy Chinese volunteers: a randomized, single-blind, crossover study

Author:

Chen Qian,Liu Yan-mei,Liu Yun,Mendzelevski Boaz,Chanter Dennis,Pu Hua-hua,Liu Gang-yi,Weng Onglee,Hu Chao-ying,Wang Wei,Yu Chen,Jia Jing-ying

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference17 articles.

1. Yan GX, Lankipalli RS, Burke JF, Musco S, Kowey PR . Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance. J Am Coll Cardiol 2003; 42: 401–9.

2. Roden DM . Drug-induced prolongation of the QT interval. N Engl J Med 2004; 350: 1013–22.

3. Strnadova C . The assessment of QT/QTc interval prolongation in clinical trials: a regulatory perspective. Drug Information J 2005; 39: 407–33.

4. International Conference on Harmonisation (ICH). ICH topic E14. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs (Step 4). 12 May 2005. Available from: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E14/E14_Guideline.pdf (last accessed on 10 September 2012).

5. E14 implementation working group: ICH E14 guideline: the clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs questions & answers (R1). 5 April 2012. available from: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E14/E14_Q_As_R1_step4.pdf (last accessed on 10 September 2012).

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