A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila-Reference-Cited by-同舟云学术

A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila

Published:2023-09-18 Issue:10 Volume:25 Page:1495-1505
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Venkei Zsolt G.,Gainetdinov Ildar^ORCID,Bagci Ayca,Starostik Margaret R.^ORCID,Choi Charlotte P.,Fingerhut Jaclyn M.^ORCID,Chen Peiwei^ORCID,Balsara Chiraag,Whitfield Troy W.^ORCID,Bell George W.,Feng Suhua,Jacobsen Steven E.^ORCID,Aravin Alexei A.^ORCID,Kim John K.,Zamore Phillip D.^ORCID,Yamashita Yukiko M.^ORCID

Abstract

AbstractIn animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In Drosophila and other species with a maternally specified germline, piRNAs deposited in the egg initiate piRNA biogenesis in the progeny. However, Y chromosome loci cannot participate in such a chain of intergenerational inheritance. How then can the biogenesis of Y-linked piRNAs be initiated? Here, using Suppressor of Stellate (Su(Ste)), a Y-linked Drosophila melanogaster piRNA locus as a model, we show that Su(Ste) piRNAs are made in the early male germline via 5′-to-3′ phased piRNA biogenesis initiated by maternally deposited 1360/Hoppel transposon piRNAs. Notably, deposition of Su(Ste) piRNAs from XXY mothers obviates the need for phased piRNA biogenesis in sons. Together, our study uncovers a developmentally programmed, intergenerational mechanism that allows fly mothers to protect their sons using a Y-linked piRNA locus.

Funder

Howard Hughes Medical Institute

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

https://www.nature.com/articles/s41556-023-01227-4.pdf

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