BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma-Reference-Cited by-同舟云学术

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Published:2020-02 Issue:2 Volume:22 Page:167-174
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Li Jin-Tao,Yin Miao,Wang Di,Wang Jian,Lei Ming-Zhu,Zhang Ye,Liu Ying,Zhang Lei,Zou Shao-Wu,Hu Li-Peng,Zhang Zhi-Gang^ORCID,Wang Yi-Ping^ORCID,Wen Wen-Yu^ORCID,Lu Hao-Jie,Chen Zheng-Jun,Su Dan,Lei Qun-Ying^ORCID

Funder

National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund

Ministry of Science and Technology of the People’s Republic of China

Shanghai Municipal Education Commission | E-Institutes of Shanghai Municipal Education Commission

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/s41556-019-0455-6.pdf

Reference34 articles.

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2. Mayers, J. R. et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat. Med. 20, 1193–1198 (2014).

3. Dey, P. et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature 542, 119–123 (2017).

4. Mayers, J. R. et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353, 1161–1165 (2016).

5. Ichihara, A. & Koyama, E. Transaminase of branched chain amino acids. I. Branched chain amino acids-α-ketoglutarate transaminase. J. Biochem. 59, 160–169 (1966).

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