IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Author:

Kofuji Satoshi,Hirayama Akiyoshi,Eberhardt Alexander Otto,Kawaguchi RisaORCID,Sugiura Yuki,Sampetrean OlteaORCID,Ikeda Yoshiki,Warren Mikako,Sakamoto Naoya,Kitahara ShujiORCID,Yoshino Hirofumi,Yamashita Daisuke,Sumita Kazutaka,Wolfe Kara,Lange Lisa,Ikeda Satsuki,Shimada Hiroko,Minami Noriaki,Malhotra Akshiv,Morioka Shin,Ban Yuki,Asano Maya,Flanary Victoria L.,Ramkissoon Annmarie,Chow Lionel M. L.,Kiyokawa Juri,Mashimo Tomoyuki,Lucey Greg,Mareninov Sergey,Ozawa Tatsuya,Onishi Nobuyuki,Okumura Koichi,Terakawa Jumpei,Daikoku Takiko,Wise-Draper Trisha,Majd Nazanin,Kofuji Kaori,Sasaki Mika,Mori Masaru,Kanemura Yonehiro,Smith Eric P.,Anastasiou DimitriosORCID,Wakimoto HiroakiORCID,Holland Eric C.ORCID,Yong William H.,Horbinski Craig,Nakano Ichiro,DeBerardinis Ralph J.,Bachoo Robert M.,Mischel Paul S.ORCID,Yasui Wataru,Suematsu MakotoORCID,Saya HideyukiORCID,Soga Tomoyoshi,Grummt Ingrid,Bierhoff Holger,Sasaki Atsuo T.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Reference70 articles.

1. Pianese, G. Beitrag zur Histologie und Aetiologie der Carcinoma. Histologische und experimentelle Untersuchungen. Beitr. Pathol. Anat. Allg. Pathol. 142, 1–193 (1896).

2. Ruggero, D. Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci. Signal. 5, pe38 (2012).

3. Hara, A. et al. Correlation between nucleolar organizer region staining and Ki-67 immunostaining in human gliomas. Surg. Neurol. 33, 320–324 (1990).

4. Busch, H., Byvoet, P. & Smetana, K. The nucleolus of the cancer cell: a review. Cancer Res. 23, 313–339 (1963).

5. Tsai, R. Y. L. & Pederson, T. Connecting the nucleolus to the cell cycle and human disease. FASEB J. 28, 3290–3296 (2014).

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