PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
https://www.nature.com/articles/s41556-023-01148-2.pdf
Reference6 articles.
1. Nargund, A. M. et al. The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Rep. 18, 2893–2906 (2017). This paper first reports initiation of clear cell RCC tumours from loss of Vhl and Pbrm1 in mouse kidney.
2. Yao, X. et al. VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma. Cancer Discov. 7, 1284–1305 (2017). This paper shows that the epigenomic effect of VHL loss involves activation of enhancers of proto-oncogenes.
3. Xiao, L. et al. Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 601, 434–439 (2022). This paper shows that degradation of SWI/SNF ATPases dislodges multiple transcription factors from the chromatin.
4. Juvekar, A. et al. Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB–dependent transcription and induction of apoptosis in CTCL. Mol. Cancer Res. 9, 183–194 (2011). This paper shows that bortezomib induces nuclear translocation and accumulation of IκBα, which associates with NF-κB and inhibits its DNA binding activity.
5. Teh, B. T. et al. Familial non-VHL non-papillary clear-cell renal cancer. Lancet 349, 848–849 (1997). This paper describes the involvement of other genes besides VHL in familial clear cell RCC.
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