p16High senescence restricts cellular plasticity during somatic cell reprogramming
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
https://www.nature.com/articles/s41556-023-01214-9.pdf
Reference42 articles.
1. Hishida, T. et al. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Rep. 39, 110730 (2022).
2. Reddy, P., Memczak, S. & Izpisua Belmonte, J. C. Unlocking tissue regenerative potential by epigenetic reprogramming. Cell Stem Cell 28, 5–7 (2021).
3. Ocampo, A. et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 167, 1719–1733.e12 (2016).
4. Baker, D. J. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011).
5. Baker, D. J. et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530, 184–189 (2016).
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