Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock
Author:
Funder
China Postdoctoral Science Foundation
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
https://www.nature.com/articles/s41556-022-00846-7.pdf
Reference60 articles.
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2. Mahat, D. B., Salamanca, H. H., Duarte, F. M., Danko, C. G. & Lis, J. T. Mammalian heat shock response and mechanisms underlying its genome-wide transcriptional regulation. Mol. Cell 62, 63–78 (2016).
3. Richter, K., Haslbeck, M. & Buchner, J. The heat shock response: life on the verge of death. Mol. Cell 40, 253–266 (2010).
4. Gomez-Pastor, R. et al. Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease. Nat. Commun. 8, 14405 (2017).
5. Mendillo, M. L. et al. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 150, 549–562 (2012).
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