ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

Published:2019-09-23 Issue:10 Volume:21 Page:1206-1218
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Lim Chun-Yan,Davis Oliver B.,Shin Hijai R.,Zhang Justin,Berdan Charles A.,Jiang Xuntian,Counihan Jessica L.,Ory Daniel S.,Nomura Daniel K.^ORCID,Zoncu Roberto^ORCID

Funder

American Heart Association

Foundation for the National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/s41556-019-0391-5.pdf

Reference64 articles.

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2. Phillips, M. J. & Voeltz, G. K. Structure and function of ER membrane contact sites with other organelles. Nat. Rev. Mol. Cell Biol. 17, 69–82 (2016).

3. Thelen, A. M. & Zoncu, R. Emerging roles for the lysosome in lipid metabolism. Trends Cell Biol. 27, 833–850 (2017).

4. Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P. & Guan, K. L. Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10, 935–945 (2008).

5. Sancak, Y. et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290–303 (2010).

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