Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis-Reference-Cited by-同舟云学术

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

Published:2008-10-26 Issue:11 Volume:14 Page:1227-1235
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Friese Manuel A,Jakobsen Karen B,Friis Lone,Etzensperger Ruth,Craner Matthew J,McMahon Róisín M,Jensen Lise T,Huygelen Véronique,Jones E Yvonne,Bell John I,Fugger Lars

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.1881.pdf

Reference50 articles.

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2. Hafler, D.A. et al. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357, 851–862 (2007).

3. Olerup, O. & Hillert, J. HLA class II–associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 38, 1–15 (1991).

4. van Oosten, B.W. et al. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial. Neurology 49, 351–357 (1997).

5. Segal, B.M. et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 7, 796–804 (2008).

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