Cas9 immunity creates challenges for CRISPR gene editing therapies-Reference-Cited by-同舟云学术

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Cas9 immunity creates challenges for CRISPR gene editing therapies

Published:2018-08-29 Issue:1 Volume:9 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Crudele Julie M.,Chamberlain Jeffrey S.

Funder

U.S. Department of Health & Human Services | National Institutes of Health

Muscular Dystrophy Association

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-018-05843-9.pdf

Reference15 articles.

1. Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819–823 (2013).

2. Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823–826 (2013).

3. Wang, H. & Sun, W. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. 385, 137–143 (2017).

4. Bengtsson, N. E. et al. Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy. Nat. Commun. 8, 14454 (2017).

5. Charlesworth, C. T. et al. Identification of pre-existing adaptive immunity to Cas9 proteins in humans. Preprint at b ioRxiv https://doi.org/10.1101/243345 (2018).

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