Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
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Published:2018-10-26
Issue:1
Volume:9
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Teumer AlexanderORCID, , Chaker Layal, Groeneweg Stefan, Li Yong, Di Munno Celia, Barbieri Caterina, Schultheiss Ulla T., Traglia Michela, Ahluwalia Tarunveer S.ORCID, Akiyama Masato, Appel Emil Vincent R.ORCID, Arking Dan E., Arnold Alice, Astrup ArneORCID, Beekman MarianORCID, Beilby John P.ORCID, Bekaert Sofie, Boerwinkle Eric, Brown Suzanne J., De Buyzere Marc, Campbell Purdey J., Ceresini Graziano, Cerqueira Charlotte, Cucca Francesco, Deary Ian J., Deelen Joris, Eckardt Kai-Uwe, Ekici Arif B.ORCID, Eriksson Johan G., Ferrrucci Luigi, Fiers Tom, Fiorillo Edoardo, Ford Ian, Fox Caroline S., Fuchsberger Christian, Galesloot Tessel E., Gieger Christian, Gögele Martin, De Grandi Alessandro, Grarup NielsORCID, Greiser Karin Halina, Haljas Kadri, Hansen TorbenORCID, Harris Sarah E., van Heemst Diana, den Heijer Martin, Hicks Andrew A.ORCID, den Hollander Wouter, Homuth Georg, Hui Jennie, Ikram M. ArfanORCID, Ittermann Till, Jensen Richard A., Jing Jiaojiao, Jukema J. WouterORCID, Kajantie Eero, Kamatani YoichiroORCID, Kasbohm Elisa, Kaufman Jean-Marc, Kiemeney Lambertus A., Kloppenburg Margreet, Kronenberg FlorianORCID, Kubo Michiaki, Lahti JariORCID, Lapauw Bruno, Li ShuoORCID, Liewald David C. M.ORCID, Lim Ee Mun, Linneberg AllanORCID, Marina Michela, Mascalzoni DeborahORCID, Matsuda Koichi, Medenwald Daniel, Meisinger Christa, Meulenbelt IngridORCID, De Meyer Tim, Meyer zu Schwabedissen Henriette E., Mikolajczyk Rafael, Moed Matthijs, Netea-Maier Romana T.ORCID, Nolte Ilja M.ORCID, Okada YukinoriORCID, Pala Mauro, Pattaro Cristian, Pedersen Oluf, Petersmann Astrid, Porcu Eleonora, Postmus Iris, Pramstaller Peter P., Psaty Bruce M., Ramos Yolande F. M.ORCID, Rawal Rajesh, Redmond Paul, Richards J. BrentORCID, Rietzschel Ernst R., Rivadeneira Fernando, Roef Greet, Rotter Jerome I., Sala Cinzia F., Schlessinger David, Selvin Elizabeth, Slagboom P. Eline, Soranzo NicoleORCID, Sørensen Thorkild I. A., Spector Timothy D., Starr John M., Stott David J., Taes Youri, Taliun Daniel, Tanaka Toshiko, Thuesen Betina, Tiller Daniel, Toniolo Daniela, Uitterlinden Andre G., Visser W. Edward, Walsh John P., Wilson Scott G., Wolffenbuttel Bruce H. R., Yang QiongORCID, Zheng Hou-Feng, Cappola Anne, Peeters Robin P., Naitza Silvia, Völzke Henry, Sanna Serena, Köttgen AnnaORCID, Visser Theo J., Medici Marco
Funder
The list of funders and grants is provided in the Supplementary Note 4 of the Supplementary Information.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference64 articles.
1. Cooper, D. S. & Biondi, B. Subclinical thyroid disease. Lancet 379, 1142–1154 (2012). 2. Chaker, L. et al. Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. J. Clin. Endocrinol. Metab. 100, 2181–2191 (2015). 3. Collet, T.-H. et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch. Intern. Med. 172, 799–809 (2012). 4. Medici, M. et al. Thyroid function within the normal range and the risk of depression: a population-based cohort study. J. Clin. Endocrinol. Metab. 99, 1213–1219 (2014). 5. Cappola, A. R. et al. Thyroid function in the euthyroid range and adverse outcomes in older adults. J. Clin. Endocrinol. Metab. 100, 1088–1096 (2015).
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