Abstract
AbstractVaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists. To investigate this, we infer a fitness model for the poliovirus viral protein 1 (vp1), which successfully predicts in vitro fitness measurements. This is achieved by first developing a probabilistic model for the prevalence of vp1 sequences that enables us to isolate and remove data that are subject to strong vaccine-derived biases. The intrinsic fitness constraints derived for vp1, a capsid protein subject to antibody responses, are compared with those of analogous HIV proteins. We find that vp1 evolution is subject to tighter constraints, limiting its ability to evade vaccine-induced immune responses. Our analysis also indicates that circulating poliovirus strains in unimmunized populations serve as a reservoir that can seed outbreaks in spatio-temporally localized sub-optimally immunized populations.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference70 articles.
1. World-Health-Organization. Poliomyleitis, Fact Sheet (2016). http://www.who.int/mediacentre/factsheets/fs114/en/ (accessed 20 July 2017).
2. World-Health-Organization. Measles, Fact Sheet (2017). http://www.who.int/mediacentre/factsheets/fs286/en/ (accessed 20 July 2017).
3. Haynes, B. F. et al. Progress in HIV-1 vaccine development. J. Allergy Clin. Immunol. 134, 3–10 (2014).
4. Honegger, J. R., Zhou, Y. & Walker, C. M. Will there be a vaccine to prevent HCV infection? Semin. Liver Dis. 34, 79–88 (2014).
5. Salk, J. E. et al. Formaldehyde treatment and safety testing of experimental poliomyelitis vaccines. Am. J. Public Health 44, 563–570 (1954).
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