Abstract
AbstractLong lasting insecticidal nets (LLINs) provide both direct and indirect protection against malaria. As pyrethroid resistance evolves in mosquito vectors, it will be useful to understand how the specific benefits LLINs afford individuals and communities may be affected. Here we use modelling to show that there is no minimum LLIN usage needed for users and non-users to benefit from community protection. Modelling results also indicate that pyrethroid resistance in local mosquitoes will likely diminish the direct and indirect benefits from insecticides, leaving the barrier effects intact, but LLINs are still expected to provide enhanced benefit over untreated nets even at high levels of pyrethroid resistance.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference85 articles.
1. Bhatt, S. et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526, 207–211 (2015).
2. WHO Malaria Policy Advisory Group. Revised Recommendations for Achieving Universal Coverage With Long-Lasting Insecticidal Nets in Malaria Control (WHO, 2017).
3. Hakizimana, E. et al. Monitoring long-lasting insecticidal net (LLIN) durability to validate net serviceable life assumptions, in Rwanda. Malar. J. 13, 344 (2014).
4. Bertozzi-Villa, A. et al. Maps and metrics of insecticide-treated net access, use, and nets-per-capita in Africa from 2000–2020. Nat. Commun. 12, 3589 (2021).
5. Koenker, H. M. et al. A good night’s sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar. Malar. J. 12, 203 (2013).