DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
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Published:2018-06-19
Issue:1
Volume:9
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Kular Lara, Liu Yun, Ruhrmann Sabrina, Zheleznyakova Galina, Marabita FrancescoORCID, Gomez-Cabrero David, James Tojo, Ewing EwoudORCID, Lindén Magdalena, Górnikiewicz Bartosz, Aeinehband Shahin, Stridh Pernilla, Link JennyORCID, Andlauer Till F. M.ORCID, Gasperi Christiane, Wiendl Heinz, Zipp FraukeORCID, Gold Ralf, Tackenberg Björn, Weber Frank, Hemmer Bernhard, Strauch Konstantin, Heilmann-Heimbach Stefanie, Rawal Rajesh, Schminke Ulf, Schmidt Carsten O., Kacprowski TimORCID, Franke AndreORCID, Laudes Matthias, Dilthey Alexander T., Celius Elisabeth G., Søndergaard Helle B., Tegnér Jesper, Harbo Hanne F., Oturai Annette B., Olafsson Sigurgeir, Eggertsson Hannes P.ORCID, Halldorsson Bjarni V.ORCID, Hjaltason Haukur, Olafsson Elias, Jonsdottir Ingileif, Stefansson Kari, Olsson Tomas, Piehl Fredrik, Ekström Tomas J., Kockum Ingrid, Feinberg Andrew P.ORCID, Jagodic Maja
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference78 articles.
1. O’Gorman, C., Lin, R., Stankovich, J. & Broadley, S. A. Modelling genetic susceptibility to multiple sclerosis with family data. Neuroepidemiology 40, 1–12 (2013). 2. Jersild, C., Svejgaard, A. & Fog, T. HL-A antigens and multiple sclerosis. Lancet 1, 1240–1241 (1972). 3. Oksenberg, J. R. et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am. J. Hum. Genet. 74, 160–167 (2004). 4. International Multiple Sclerosis Genetics, C. et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214–219 (2011). 5. Moutsianas, L. et al. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat. Genet. 47, 1107–1113 (2015).
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