A sandcastle worm-inspired strategy to functionalize wet hydrogels

Author:

Zhang DonghuiORCID,Liu Jingjing,Chen QiORCID,Jiang Weinan,Wang Yibing,Xie Jiayang,Ma Kaiqian,Shi Chao,Zhang HaodongORCID,Chen Minzhang,Wan Jianglin,Ma PengchengORCID,Zou JingchengORCID,Zhang WenjingORCID,Zhou Feng,Liu RunhuiORCID

Abstract

AbstractHydrogels have been extensively used in many fields. Current synthesis of functional hydrogels requires incorporation of functional molecules either before or during gelation via the pre-organized reactive site along the polymer chains within hydrogels, which is tedious for polymer synthesis and not flexible for different types of hydrogels. Inspired by sandcastle worm, we develop a simple one-step strategy to functionalize wet hydrogels using molecules bearing an adhesive dibutylamine-DOPA-lysine-DOPA tripeptide. This tripeptide can be easily modified with various functional groups to initiate diverse types of polymerizations and provide functional polymers with a terminal adhesive tripeptide. Such functional molecules enable direct modification of wet hydrogels to acquire biological functions such as antimicrobial, cell adhesion and wound repair. The strategy has a tunable functionalization degree and a stable attachment of functional molecules, which provides a tool for direct and convenient modification of wet hydrogels to provide them with diverse functions and applications.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

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