A naturally protective epitope of limited variability as an influenza vaccine target

Author:

Thompson Craig P.ORCID,Lourenço JoséORCID,Walters Adam A.,Obolski Uri,Edmans Matthew,Palmer Duncan S.ORCID,Kooblall Kreepa,Carnell George W.,O’Connor DanielORCID,Bowden Thomas A.,Pybus Oliver G.,Pollard Andrew J.,Temperton Nigel J.ORCID,Lambe Teresa,Gilbert Sarah C.ORCID,Gupta Sunetra

Funder

EC | European Research Council

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference40 articles.

1. World Health Organization. Influenza WHO fact sheet no. 211. at <  https://www.who.int/mediacentre/factsheets/fs211/en / >  (Geneva, Switzerland, 2009).

2. Paules, C. & Subbarao, K. Influenza. Lancet 390, 697–708 (2017).

3. Caton, A. J., Brownlee, G. G., Yewdell, J. W. & Gerhard, W. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell 31, 417–427 (1982).

4. Wiley, D. C., Wilson, I. A. & Skehel, J. J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289, 373–378 (1981).

5. Skehel, J. J. et al. A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody. Cell 81, 1779–1783 (1984).

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