Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

Author:

Garofalo StefanoORCID,Cocozza Germana,Mormino AlessandroORCID,Bernardini GiovanniORCID,Russo Eleonora,Ielpo DonaldORCID,Andolina Diego,Ventura RossellaORCID,Martinello Katiuscia,Renzi MassimilianoORCID,Fucile SergioORCID,Laffranchi Mattia,Mortari Eva PianoORCID,Carsetti RitaORCID,Sciumè Giuseppe,Sozzani Silvano,Santoni Angela,Tremblay Marie-EveORCID,Ransohoff Richard M.,Limatola CristinaORCID

Abstract

AbstractThe mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.

Funder

Ministero della Salute

Sapienza Università di Roma

Ministero dell'Istruzione, dell'Università e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

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