A comprehensive genetic map of cytokine responses in Lyme borreliosis-Reference-Cited by-同舟云学术

A comprehensive genetic map of cytokine responses in Lyme borreliosis

Published:2024-05-07 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Botey-Bataller Javier^ORCID,Vrijmoeth Hedwig D.^ORCID,Ursinus Jeanine,Kullberg Bart-Jan,van den Wijngaard Cees C.,ter Hofstede Hadewych,Alaswad Ahmed,Gupta Manoj K.,Roesner Lennart M.^ORCID,Huehn Jochen^ORCID,Werfel Thomas,Schulz Thomas F.^ORCID,Xu Cheng-Jian,Netea Mihai G.^ORCID,Hovius Joppe W.,Joosten Leo A. B.^ORCID,Li Yang^ORCID

Abstract

AbstractThe incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine production capacity before and after antibiotic treatment in 1,060 Lyme borreliosis patients. We observed a negative correlation between antibody production and IL-10 responses, as well as increased IL-1Ra responses in patients with disseminated disease. Genome-wide mapping the cytokine production allowed us to identify 34 cytokine quantitative trait loci (cQTLs), with 31 novel ones. We pinpointed the causal variant at the TLR1-6-10 locus and validated the regulation of IL-1Ra responses at transcritpome level using an independent cohort. We found that cQTLs contribute to Lyme borreliosis susceptibility and are relevant to other immune-mediated diseases. Our findings improve the understanding of cytokine responses in Lyme borreliosis and provide a genetic map of immune function as an expanded resource.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-47505-z.pdf

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