Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
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Published:2019-06-03
Issue:1
Volume:10
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Bandopadhayay Pratiti, Piccioni FedericaORCID, O’Rourke Ryan, Ho Patricia, Gonzalez Elizabeth M., Buchan Graham, Qian Kenin, Gionet Gabrielle, Girard Emily, Coxon Margo, Rees Matthew G.ORCID, Brenan Lisa, Dubois Frank, Shapira Ofer, Greenwald Noah F.ORCID, Pages Melanie, Balboni Iniguez Amanda, Paolella Brenton R., Meng Alice, Sinai Claire, Roti Giovanni, Dharia Neekesh V.ORCID, Creech Amanda, Tanenbaum Benjamin, Khadka Prasidda, Tracy Adam, Tiv Hong L.ORCID, Hong Andrew L.ORCID, Coy Shannon, Rashid Rumana, Lin Jia-RenORCID, Cowley Glenn S.ORCID, Lam Fred C., Goodale Amy, Lee Yenarae, Schoolcraft Kathleen, Vazquez FranciscaORCID, Hahn William C.ORCID, Tsherniak AviadORCID, Bradner James E.ORCID, Yaffe Michael B., Milde Till, Pfister Stefan M., Qi Jun, Schenone MonicaORCID, Carr Steven A., Ligon Keith L., Kieran Mark W., Santagata SandroORCID, Olson James M., Gokhale Prafulla C., Jaffe Jacob D.ORCID, Root David E.ORCID, Stegmaier Kimberly, Johannessen Cory M., Beroukhim RameenORCID
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference61 articles.
1. Cho, Y.-J. et al. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J. Clin. Oncol. 29, 1424–1430 (2011). 2. Northcott, P. A., Korshunov, A. & Witt, H. Medulloblastoma comprises four distinct molecular variants. J. Clin
. Oncol. 29, 1408 (2011). 3. Kool, M. et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 123, 473–484 (2012). 4. Delmore, J. E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904–917 (2011). 5. Puissant, A. et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 3, 308–323 (2013).
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