B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-07626-8.pdf
Reference54 articles.
1. Overman, C. L. et al. Change of psychological distress and physical disability in patients with rheumatoid arthritis over the last two decades. Arthritis Care Res. 66, 671–678 (2014).
2. Amarasekara, D. S., Yu, J. & Rho, J. Bone loss triggered by the cytokine network in inflammatory autoimmune diseases. J. Immunol. Res. 2015, 832127 (2015).
3. Danks, L. et al. RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation. Ann. Rheum. Dis. 75, 1187–1195 (2016).
4. Meednu, N. et al. Production of RANKL by memory B cells: a link between B cells and bone erosion in rheumatoid arthritis. Arthritis Rheumatol. 68, 805–816 (2016).
5. Miranda-Carus, M. E. et al. Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes. Arthritis Rheum. 54, 1151–1164 (2006).
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