Genetic diversity of SARS-CoV-2 infections in Ghana from 2020-2021
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Published:2022-05-06
Issue:1
Volume:13
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Morang’a Collins M.ORCID, Ngoi Joyce M., Gyamfi Jones, Amuzu Dominic S. Y., Nuertey Benjamin D.ORCID, Soglo Philip M., Appiah Vincent, Asante Ivy A., Owusu-Oduro Paul, Armoo Samuel, Adu-Gyasi DennisORCID, Amoako Nicholas, Oliver-Commey Joseph, Owusu MichaelORCID, Sylverken Augustina, Fenteng Edward D., M’cormack Violette V., Tei-Maya FrederickORCID, Quansah Evelyn B., Ayivor-Djanie ReubenORCID, Amoako Enock K., Ogbe Isaac T., Yemi Bright K., Osei-Wusu IsraelORCID, Mettle Deborah N. A., Saiid Samirah, Tapela Kesego, Dzabeng Francis, Magnussen Vanessa, Quaye JerryORCID, Opurum Precious C., Carr Rosina A.ORCID, Ababio Patrick T., Abass Abdul-Karim, Akoriyea Samuel K., Amoako Emmanuella, Kumi-Ansah FrederickORCID, Boakye Oliver D., Mibut Dam K., Odoom Theophilus, Ofori-Boadu Lawrence, Allegye-Cudjoe Emmanuel, Dassah Sylvester, Asoala Victor, Asante Kwaku P., Phillips Richard O., Osei-Atweneboana Mike Y., Gyapong John O., Kuma-Aboagye Patrick, Ampofo William K., Duedu Kwabena O.ORCID, Ndam Nicaise T., Bediako Yaw, Quashie Peter K.ORCID, Amenga-Etego Lucas N.ORCID, Awandare Gordon A.ORCID
Abstract
AbstractThe COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana. The data show that initial local transmission was dominated by B.1.1 lineage, but the second wave was overwhelmingly driven by the Alpha variant. Subsequently, an unheralded variant under monitoring, B.1.1.318, dominated transmission from April to June 2021 before being displaced by Delta variants, which were introduced into community transmission in May 2021. Mutational analysis indicated that variants that took hold in Ghana harboured transmission enhancing and immune escape spike substitutions. The observed rapid viral evolution demonstrates the potential for emergence of novel variants with greater mutational fitness as observed in other parts of the world.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference30 articles.
1. World Health Organization. Coronavirus (COVID-19) Dashboard (2021). https://covid19.who.int. 2. Ghana Health Service. Ghana COVID-19 Situation Dashboard (2021). https://www.ghs.gov.gh/covid19/dashboardm.php. 3. Tan, C-W. et al. Pan-sarbecovirus neutralizing antibodies in BNT162b2-immunized SARS-CoV-1 survivors. N. Engl. J. Med. 385, 1401–1406 (2021). 4. Ghana Health Service. COVID-19: Ghana’s Outbreak Response Management Updates (2021). https://www.ghs.gov.gh/covid19/. 5. Quashie, P. K. et al. Trends of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody prevalence in selected regions across Ghana. Wellcome Open Res. 6, 173 (2021).
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