Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
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Published:2020-11-25
Issue:1
Volume:11
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Steinthorsdottir ValgerdurORCID, , McGinnis RalphORCID, Williams Nicholas O.ORCID, Stefansdottir Lilja, Thorleifsson Gudmar, Shooter Scott, Fadista João, Sigurdsson Jon K., Auro Kirsi M., Berezina GalinaORCID, Borges Maria-Carolina, Bumpstead Suzannah, Bybjerg-Grauholm JonasORCID, Colgiu Irina, Dolby Vivien A., Dudbridge FrankORCID, Engel Stephanie M., Franklin Christopher S.ORCID, Frigge Michael L., Frisbaek Yr, Geirsson Reynir T., Geller FrankORCID, Gretarsdottir Solveig, Gudbjartsson Daniel F.ORCID, Harmon Quaker, Hougaard David MichaelORCID, Hegay Tatyana, Helgadottir AnnaORCID, Hjartardottir Sigrun, Jääskeläinen TiinaORCID, Johannsdottir Hrefna, Jonsdottir IngileifORCID, Juliusdottir Thorhildur, Kalsheker Noor, Kasimov Abdumadjit, Kemp John P.ORCID, Kivinen KatjaORCID, Klungsøyr Kari, Lee Wai K., Melbye MadsORCID, Miedzybrodska Zosia, Moffett AshleyORCID, Najmutdinova Dilbar, Nishanova Firuza, Olafsdottir Thorunn, Perola Markus, Pipkin Fiona BroughtonORCID, Poston Lucilla, Prescott GordonORCID, Saevarsdottir SaedisORCID, Salimbayeva Damilya, Scaife Paula Juliet, Skotte LineORCID, Staines-Urias Eleonora, Stefansson Olafur A.ORCID, Sørensen Karina Meden, Thomsen Liv Cecilie Vestrheim, Tragante Vinicius, Trogstad Lill, Simpson Nigel A. B.ORCID, Aripova Tamara, Casas Juan P., Dominiczak Anna F.ORCID, Walker James J.ORCID, Thorsteinsdottir Unnur, Iversen Ann-CharlotteORCID, Feenstra BjarkeORCID, Lawlor Deborah A.ORCID, Boyd Heather AllisonORCID, Magnus Per, Laivuori HanneleORCID, Zakhidova Nodira, Svyatova GulnaraORCID, Stefansson KariORCID, Morgan LindaORCID,
Abstract
AbstractPreeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Funder
EC | EC Seventh Framework Programm | FP7 Health British Heart Foundation Samfund og Erhverv, Det Frie Forskningsråd U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development Wellcome Trust
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
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