Abstract
AbstractBrain lesions do not just disable but also disconnect brain areas, which once deprived of their input or output, can no longer subserve behaviour and cognition. The role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions, here we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former has granted us the possibility to map 590 functions on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. Overall, our freely available Atlas of White Matter Function will enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for explorations in the domain of cognition.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference53 articles.
1. Bacon, F. Novum Organum with Other Parts of the Great Instauration (John Bill, London, 1620).
2. Searle, J. R. Seeing Things as They are (Oxford University Press, 2015).
3. Bogen, J. & Woodward, J. Saving the phenomena. Philos. Rev. XCVII (3), 303–352 (1988).
4. Damasio, H. & Damasio, A. Lesion Analysis in Neuropsychology (1989).
5. Vaidya, A. R., Pujara, M. S., Petrides, M., Murray, E. A. & Fellows, L. K. Lesion studies in contemporary neuroscience. Trends Cogn. Sci. 23, 653–671 (2019).
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