Abstract
AbstractThe dorsal raphe nucleus (DRN) is known to control aggressive behavior in mice. Here, we found that glutamatergic projections from the lateral habenula (LHb) to the DRN were activated in male mice that experienced pre-exposure to a rival male mouse (“social instigation”) resulting in heightened intermale aggression. Both chemogenetic and optogenetic suppression of the LHb-DRN projection blocked heightened aggression after social instigation in male mice. In contrast, inhibition of this pathway did not affect basal levels of aggressive behavior, suggesting that the activity of the LHb-DRN projection is not necessary for the expression of species-typical aggressive behavior, but required for the increase of aggressive behavior resulting from social instigation. Anatomical analysis showed that LHb neurons synapse on non-serotonergic DRN neurons that project to the ventral tegmental area (VTA), and optogenetic activation of the DRN-VTA projection increased aggressive behaviors. Our results demonstrate that the LHb glutamatergic inputs to the DRN promote aggressive arousal induced by social instigation, which contributes to aggressive behavior by activating VTA-projecting non-serotonergic DRN neurons as one of its potential targets.
Funder
MEXT | Japan Society for the Promotion of Science
MEXT | JST | Adaptable and Seamless Technology Transfer Program through Target-Driven R and D
MEXT | Japan Science and Technology Agency
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference47 articles.
1. Archer, J. & Huntingford, F. Game theory models and escalation of animal fights. in The Dynamics of Aggression: Biological and Social Processes in Dyads and Groups (eds. Potegal, M. & Kuntson, J. F.) 3–33 (Lawrence Erlbaum Associates, 1994).
2. Heiligenberg, W. The effect of external stimuli on the attack readiness of a cichlid fish. Z. Vgl. Physiol. 49, 459–464 (1965).
3. Potegal, M. Time course of aggressive arousal in female hamsters and male rats. Behav. Neural Biol. 58, 120–124 (1992).
4. Fish, E. W., Faccidomo, S. & Miczek, K. A. Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146, 391–399 (1999).
5. Potegal, M. Aggressive arousal: the amygdala connection. in The Dynamics of Aggression: Biological and Social Processes in Dyads and Groups (eds. Potegal, M. & Knutson, J. F.) 73–132 (Lawrence Erlbaum Associates, 1994).
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