Molecular insights into antibiotic resistance - how a binding protein traps albicidin-Reference-Cited by-同舟云学术

Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Published:2018-08-06 Issue:1 Volume:9 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Rostock Lida,Driller Ronja^ORCID,Grätz Stefan,Kerwat Dennis,von Eckardstein Leonard,Petras Daniel^ORCID,Kunert Maria,Alings Claudia,Schmitt Franz-Josef,Friedrich Thomas^ORCID,Wahl Markus C.^ORCID,Loll Bernhard^ORCID,Mainz Andi^ORCID,Süssmuth Roderich D.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-018-05551-4.pdf

Reference57 articles.

1. Delcour, A. H. Outer membrane permeability and antibiotic resistance. Biochim. Biophys. Acta 1794, 808–816 (2009).

2. Royer, M. et al. Albicidin pathotoxin produced by Xanthomonas albilineans is encoded by three large PKS and NRPS genes present in a gene cluster also containing several putative modifying, regulatory, and resistance genes. Mol. Plant Microbe Interact. 17, 414–427 (2004).

3. Hashimi, S. M., Wall, M. K., Smith, A. B., Maxwell, A. & Birch, R. G. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob. Agents Chemother. 51, 181–187 (2007).

4. Kretz, J. et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew. Chem. Int. Ed. Engl. 54, 1969–1973 (2015).

5. Cociancich, S. et al. The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine. Nat. Chem. Biol. 11, 195–197 (2015).

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