Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Author:

Kaur GurmanORCID,Porter Caroline B. M.,Ashenberg Orr,Lee Jack,Riesenfeld Samantha J.ORCID,Hofree MatanORCID,Aggelakopoulou Maria,Subramanian AyshwaryaORCID,Kuttikkatte Subita Balaram,Attfield Kathrine E.ORCID,Desel Christiane A. E.ORCID,Davies Jessica L.ORCID,Evans Hayley G.,Avraham-Davidi InbalORCID,Nguyen Lan T.,Dionne Danielle A.,Neumann Anna E.ORCID,Jensen Lise Torp,Barber Thomas R.,Soilleux ElizabethORCID,Carrington MaryORCID,McVean GilORCID,Rozenblatt-Rosen OritORCID,Regev Aviv,Fugger LarsORCID

Abstract

AbstractFetal growth restriction (FGR) affects 5–10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited because FGR pathogenesis is poorly understood. Genetic studies implicateKIRandHLAgenes in FGR, however, linkage disequilibrium, genetic influence from both parents, and challenges with investigating human pregnancies make the risk alleles and their functional effects difficult to map. Here, we demonstrate that the interaction between the maternal KIR2DL1, expressed on uterine natural killer (NK) cells, and the paternally inherited HLA-C*0501, expressed on fetal trophoblast cells, leads to FGR in a humanized mouse model. We show that the KIR2DL1 and C*0501 interaction leads to pathogenic uterine arterial remodeling and modulation of uterine NK cell function. This initial effect cascades to altered transcriptional expression and intercellular communication at the maternal-fetal interface. These findings provide mechanistic insight into specific FGR risk alleles, and provide avenues of prevention and treatment.

Funder

Wellcome Trust

RCUK | Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

Reference162 articles.

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