QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration

Author:

Advani Jayshree,Mehta Puja A.ORCID,Hamel Andrew R.ORCID,Mehrotra Sudeep,Kiel ChristinaORCID,Strunz Tobias,Corso-Díaz Ximena,Kwicklis Madeline,van Asten Freekje,Ratnapriya Rinki,Chew Emily Y.ORCID,Hernandez Dena G.,Montezuma Sandra R.,Ferrington Deborah A.,Weber Bernhard H. F.ORCID,Segrè Ayellet V.,Swaroop AnandORCID

Abstract

AbstractDNA methylation provides a crucial epigenetic mark linking genetic variations to environmental influence. We have analyzed array-based DNA methylation profiles of 160 human retinas with co-measured RNA-seq and >8 million genetic variants, uncovering sites of genetic regulation in cis (37,453 methylation quantitative trait loci and 12,505 expression quantitative trait loci) and 13,747 DNA methylation loci affecting gene expression, with over one-third specific to the retina. Methylation and expression quantitative trait loci show non-random distribution and enrichment of biological processes related to synapse, mitochondria, and catabolism. Summary data-based Mendelian randomization and colocalization analyses identify 87 target genes where methylation and gene-expression changes likely mediate the genotype effect on age-related macular degeneration. Integrated pathway analysis reveals epigenetic regulation of immune response and metabolism including the glutathione pathway and glycolysis. Our study thus defines key roles of genetic variations driving methylation changes, prioritizes epigenetic control of gene expression, and suggests frameworks for regulation of macular degeneration pathology by genotype–environment interaction in retina.

Funder

U.S. Department of Health & Human Services | NIH | National Eye Institute

Deutsche Forschungsgemeinschaft

Publisher

Springer Science and Business Media LLC

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