Abstract
AbstractIn 2022, a global outbreak of mpox occurred, predominantly impacting men who have sex with men (MSM). The rapid decline of this epidemic is yet to be fully understood. We investigated the Italian outbreak by means of an individual-based mathematical model calibrated to surveillance data. The model accounts for transmission within the MSM sexual contact network, in recreational and sex clubs attended by MSM, and in households. We indicate a strong spontaneous reduction in sexual transmission (61-87%) in affected MSM communities as the possible driving factor for the rapid decline in cases. The MSM sexual contact network was the main responsible for transmission (about 80%), with clubs and households contributing residually. Contact tracing prevented about half of the potential cases, and a higher success rate in tracing contacts could significantly amplify its effectiveness. Notably, immunizing the 23% of MSM with the highest sexual activity (10 or more partners per year) could completely prevent new mpox resurgences. This research underscores the importance of augmenting contact tracing, targeted immunization campaigns of high-risk groups, and fostering reactive behavioral changes as key strategies to manage and prevent the spread of emerging sexually transmitted pathogens like mpox within the MSM community.
Funder
EC | Horizon 2020 Framework Programme
Publisher
Springer Science and Business Media LLC
Reference27 articles.
1. Damaso, C. R. Phasing out monkeypox: mpox is the new name for an old disease. Lancet Reg. Health Am. 17, 100424 (2023).
2. Multi-country outbreak of mpox, External situation report #18 - 16 March 2023. https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox--external-situation-report-−18--−16-march-2023.
3. Mpox (monkeypox) outbreak 2022. https://www.who.int/emergencies/situations/monkeypox-oubreak-2022.
4. Laurenson-Schafer, H. et al. Description of the first global outbreak of mpox: an analysis of global surveillance data. Lancet Glob. Health 11, e1012–e1023 (2023).
5. Beer, E. M. & Rao, V. B. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Negl. Trop. Dis. 13, e0007791 (2019).
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