Abstract
AbstractAdhesives with both robust adhesion and tunable degradability are clinically and ecologically vital, but their fabrication remains a formidable challenge. Here we propose an in situ radical ring-opening polymerization (rROP) strategy to design a backbone-degradable robust adhesive (BDRA) in physiological environment. The hydrophobic cyclic ketene acetal and hydrophilic acrylate monomer mixture of the BDRA precursor allows it to effectively wet and penetrate substrates, subsequently forming a deep covalently interpenetrating network with a degradable backbone via redox-initiated in situ rROP. The resulting BDRAs show good adhesion strength on diverse materials and tissues (e.g., wet bone >16 MPa, and porcine skin >150 kPa), higher than that of commercial cyanoacrylate superglue (~4 MPa and 56 kPa). Moreover, the BDRAs have enhanced tunable degradability, mechanical modulus (100 kPa-10 GPa) and setting time (seconds-hours), and have good biocompatibility in vitro and in vivo. This family of BDRAs expands the scope of medical adhesive applications and offers an easy and environmentally friendly approach for engineering.
Funder
National Key Research and Development Program of China
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference49 articles.
1. Taboada, G. M. et al. Overcoming the translational barriers of tissue adhesives. Nat. Rev. Mater. 5, 310–329 (2020).
2. Nam, S. & Mooney, D. Polymeric tissue adhesives. Chem. Rev. 121, 11336–11384 (2021).
3. Li, J. et al. Tough adhesives for diverse wet surfaces. Science 357, 378–381 (2017).
4. Fan, H. et al. Adjacent cationic-aromatic sequences yield strong electrostatic adhesion of hydrogels in seawater. Nat. Commun. 10, 5127 (2019).
5. Ma, C. et al. Ultra-strong bio-glue from genetically engineered polypeptides. Nat. Commun. 12, 3613 (2021).