Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Author:

Haikala Heidi M.ORCID,Anttila Johanna M.,Marques Elsa,Raatikainen Tiina,Ilander Mette,Hakanen Henna,Ala-Hongisto Hanna,Savelius Mariel,Balboa DiegoORCID,Von Eyss BjoernORCID,Eskelinen Vilja,Munne Pauliina,Nieminen Anni I.,Otonkoski TimoORCID,Schüler Julia,Laajala Teemu D.,Aittokallio TeroORCID,Sihto HarriORCID,Mattson Johanna,Heikkilä Päivi,Leidenius Marjut,Joensuu Heikki,Mustjoki SatuORCID,Kovanen Panu,Eilers MartinORCID,Leverson Joel D.,Klefström Juha

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference59 articles.

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2. Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61–70 (2012).

3. Deming, S. L., Nass, S. J., Dickson, R. B. & Trock, B. J. C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance. Br. J. Cancer 83, 1688–1695 (2000).

4. Stephens, P. J. et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 486, 400–404 (2012).

5. Naidu, R., Wahab, N. A., Yadav, M. & Kutty, M. K. Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction. Int. J. Mol. Med. 9, 189–196 (2002).

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