Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-019-08833-7.pdf
Reference46 articles.
1. Renwick, S. B., Snell, K. & Baumann, U. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy. Structure 6, 1105–1116 (1998).
2. Locasale, J. W. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13, 572–583 (2013).
3. Nzila, A., Ward, S. A., Marsh, K., Sims, P. F. G. & Hyde, J. E. Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy. Trends Parasitol. 21, 292–298 (2005).
4. Ducker, G. S. & Rabinowitz, J. D. Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 25, 27–42 (2017).
5. Jain, M. et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336, 1040–1044 (2012).
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