Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS-Reference-Cited by-同舟云学术

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Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS

Published:2024-09-10 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Hayashi Miyuki^ORCID,Girdhar Amandeep,Ko Ying-Hui,Kim Kevin M.^ORCID,DePierro Jacquelyn A.,Buchler Joseph R.,Arunprakash Nikhita^ORCID,Bajaj Aditya,Cingolani Gino^ORCID,Guo Lin^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

Bruno and Ilse Frick Foundation for Research on ALS

Dr. Ralph and Marian Falk Medical Research Trust

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-52151-6.pdf

Reference78 articles.

1. Portz, B., Lee, B. L. & Shorter, J. FUS and TDP-43 phases in health and disease. Trends Biochem. Sci. 46, 550–563 (2021).

2. Carey, J. L. & Guo, L. Liquid-liquid phase separation of TDP-43 and FUS in physiology and pathology of neurodegenerative diseases. Front. Mol. Biosci. 9, 826719 (2022).

3. Harrison, A. F. & Shorter, J. RNA-binding proteins with prion-like domains in health and disease. Biochem. J. 474, 1417–1438 (2017).

4. Purice, M. D. & Taylor, J. P. Linking hnRNP function to ALS and FTD pathology. Front. Neurosci. 12, 326 (2018).

5. Hock, E. M. et al. Hypertonic stress causes cytoplasmic translocation of neuronal, but not astrocytic, FUS due to impaired transportin function. Cell Rep. 24, 987–1000.e1007 (2018).

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