Abstract
AbstractWe experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference78 articles.
1. Felleman, D. J. & Van Essen, D. C. Distributed hierarchical processing in the primate cerebral cortex. Cereb. Cortex N. Y. N. 1991 1, 1–47 (1991).
2. Jones, E. G. & Powell, T. P. An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain J. Neurol. 93, 793–820 (1970).
3. Fishman, M. C. & Michael, P. Integration of auditory information in the cat’s visual cortex. Vis. Res. 13, 1415–1419 (1973).
4. Ibrahim, L. A. et al. Cross-modality sharpening of visual cortical processing through layer-1-mediated inhibition and disinhibition. Neuron 89, 1031–1045 (2016).
5. Iurilli, G. et al. Sound-driven synaptic inhibition in primary visual cortex. Neuron 73, 814–828 (2012).
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