Regulating voltage-gated ion channels with nanobodies
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Link
https://www.nature.com/articles/s41467-022-35027-5.pdf
Reference13 articles.
1. Morgenstern T. J. et al. Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody. Nat. Commun. https://doi.org/10.1038/s41467-022-35025-7 (2022).
2. Dong, Y. et al. Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2. Cell Rep. 37, 109931 (2021).
3. Wu, J. et al. Structure of the voltage-gated calcium channel Cav1.1 complex. Science 350, aad2395 (2015).
4. Davies, A. et al. The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc. Natl Acad. Sci. USA 107, 1654–1659 (2010).
5. Pragnell, M. et al. Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature 368, 67–70 (1994).
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