Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-08162-1.pdf
Reference44 articles.
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4. Chen, Y. J. et al. Identification of phosphorylation sites in the COOH-terminal tail of the mu-opioid receptor. J. Neurochem. 124, 189–199 (2013).
5. Doll, C. et al. Agonist-selective patterns of micro-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. Br. J. Pharmacol. 164, 298–307 (2011).
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