Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas-Reference-Cited by-同舟云学术

Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

Published:2021-06-15 Issue:1 Volume:12 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Stępniak Karolina,Machnicka Magdalena A.^ORCID,Mieczkowski Jakub^ORCID,Macioszek Anna,Wojtaś Bartosz^ORCID,Gielniewski Bartłomiej,Poleszak Katarzyna^ORCID,Perycz Malgorzata,Król Sylwia K.,Guzik Rafał,Dąbrowski Michał J.^ORCID,Dramiński Michał,Jardanowska Marta,Grabowicz Ilona,Dziedzic Agata,Kranas Hanna^ORCID,Sienkiewicz Karolina,Diamanti Klev^ORCID,Kotulska Katarzyna,Grajkowska Wiesława,Roszkowski Marcin,Czernicki Tomasz,Marchel Andrzej,Komorowski Jan^ORCID,Kaminska Bozena^ORCID,Wilczyński Bartek^ORCID

Abstract

AbstractChromatin structure and accessibility, and combinatorial binding of transcription factors to regulatory elements in genomic DNA control transcription. Genetic variations in genes encoding histones, epigenetics-related enzymes or modifiers affect chromatin structure/dynamics and result in alterations in gene expression contributing to cancer development or progression. Gliomas are brain tumors frequently associated with epigenetics-related gene deregulation. We perform whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples to unravel epigenetic dysfunctions driving gliomagenesis. Based on the results of the integrative analysis of the acquired profiles, we create an atlas of active enhancers and promoters in benign and malignant gliomas. We explore these elements and intersect with Hi-C data to uncover molecular mechanisms instructing gene expression in gliomas.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

https://www.nature.com/articles/s41467-021-23922-2.pdf

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