Genome-wide association study identifies susceptibility loci for acute myeloid leukemia-Reference-Cited by-同舟云学术

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Published:2021-10-29 Issue:1 Volume:12 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Lin Wei-Yu^ORCID,Fordham Sarah E.,Hungate Eric,Sunter Nicola J.,Elstob Claire^ORCID,Xu Yaobo,Park Catherine,Quante Anne,Strauch Konstantin,Gieger Christian^ORCID,Skol Andrew,Rahman Thahira,Sucheston-Campbell Lara,Wang Junke,Hahn Theresa^ORCID,Clay-Gilmour Alyssa I.,Jones Gail L.,Marr Helen J.,Jackson Graham H.,Menne Tobias,Collin Mathew^ORCID,Ivey Adam,Hills Robert K.,Burnett Alan K.^ORCID,Russell Nigel H.,Fitzgibbon Jude^ORCID,Larson Richard A.^ORCID,Le Beau Michelle M.,Stock Wendy,Heidenreich Olaf,Alharbi Abrar,Allsup David J.^ORCID,Houlston Richard S.^ORCID,Norden Jean,Dickinson Anne M.,Douglas Elisabeth,Lendrem Clare^ORCID,Daly Ann K.,Palm Louise,Piechocki Kim,Jeffries Sally,Bornhäuser Martin,Röllig Christoph,Altmann Heidi,Ruhnke Leo,Kunadt Desiree,Wagenführ Lisa,Cordell Heather J.^ORCID,Darlay Rebecca,Andersen Mette K.,Fontana Maria C.,Martinelli Giovanni,Marconi Giovanni^ORCID,Sanz Miguel A.^ORCID,Cervera José,Gómez-Seguí Inés,Cluzeau Thomas,Moreilhon Chimène,Raynaud Sophie,Sill Heinz^ORCID,Voso Maria Teresa^ORCID,Lo-Coco Francesco,Dombret Hervé,Cheok Meyling^ORCID,Preudhomme Claude,Gale Rosemary E.,Linch David,Gaal-Wesinger Julia,Masszi Andras,Nowak Daniel^ORCID,Hofmann Wolf-Karsten,Gilkes Amanda,Porkka Kimmo,Milosevic Feenstra Jelena D.,Kralovics Robert,Grimwade David,Meggendorfer Manja,Haferlach Torsten,Krizsán Szilvia^ORCID,Bödör Csaba^ORCID,Stölzel Friedrich^ORCID,Onel Kenan^ORCID,Allan James M.^ORCID

Abstract

AbstractAcute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

Funder

Blood Cancer UK

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

https://www.nature.com/articles/s41467-021-26551-x.pdf

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