A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates
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Published:2019-09-30
Issue:1
Volume:10
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Yin YuelanORCID, Yao HaoORCID, Doijad Swapnil, Kong SuweiORCID, Shen YangORCID, Cai XuexueORCID, Tan WeijunORCID, Wang YutingORCID, Feng YouweiORCID, Ling ZhitingORCID, Wang GuoliangORCID, Hu YachenORCID, Lian KaiORCID, Sun XinyuORCID, Liu YuliangORCID, Wang ChuanbinORCID, Jiao KuhuaORCID, Liu GuopingORCID, Song RuilongORCID, Chen XiangORCID, Pan ZhimingORCID, Loessner Martin J., Chakraborty TrinadORCID, Jiao Xin’anORCID
Abstract
Abstract
The foodborne pathogen Listeria monocytogenes (Lm) is a highly heterogeneous species and currently comprises of 4 evolutionarily distinct lineages. Here, we characterize isolates from severe ovine listeriosis outbreaks that represent a hybrid sub-lineage of the major lineage II (HSL-II) and serotype 4h. HSL-II isolates are highly virulent and exhibit higher organ colonization capacities than well-characterized hypervirulent strains of Lm in an orogastric mouse infection model. The isolates harbour both the Lm Pathogenicity Island (LIPI)-1 and a truncated LIPI-2 locus, encoding sphingomyelinase (SmcL), a virulence factor required for invasion and bacterial translocation from the gut, and other non-contiguous chromosomal segments from another pathogenic species, L. ivanovii. HSL-II isolates exhibit a unique wall teichoic acid (WTA) structure essential for resistance to antimicrobial peptides, bacterial invasion and virulence. The discovery of isolates harbouring pan-species virulence genes of the genus Listeria warrants global efforts to identify further hypervirulent lineages of Lm.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
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