Abstract
AbstractThe hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum–ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference43 articles.
1. Bird, C. M. & Burgess, N. The hippocampus and memory: insights from spatial processing. Nat. Rev. Neurosci. 9, 182–194 (2008).
2. Vetere, G. et al. Chemogenetic interrogation of a brain-wide fear memory network in mice. Neuron 94, 363–374.e4 (2017).
3. Del Ferraro, G. et al. Finding influential nodes for integration in brain networks using optimal percolation theory. Nat. Commun. 9, 1–12 (2018).
4. Park, H. J. & Friston, K. Structural and functional brain networks: from connections to cognition. Science 342, 1238411 (2013).
5. Setlow, B. & McGaugh, J. L. Differential effects of immediate posttraining sulpiride microinfusions into the nucleus accumbens shell and core on Morris water maze retention. Psychobiology 27, 248–255 (1999).
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