Abstract
AbstractThe extent of SARS-CoV-2 circulation in many African countries remains unclear, underlining the need for antibody sero-surveys to assess the cumulative attack rate. Here, we present the results of a cross-sectional sero-survey of a random sample of residents of a health district in Yaounde, Cameroon, conducted from October 14 to November 26, 2020. Among the 971 participants, the test-adjusted seroprevalence of anti-SARS-CoV-2 IgG antibodies was 29·2% (95% CI 24·3–34·1). This is about 322 times greater than the 0.09% nationwide attack rate implied by COVID-19 case counts at the time. Men, obese individuals and those living in large households were significantly more likely to be seropositive, and the majority (64·2% [58·7–69·4]) of seropositive individuals reported no symptoms. Despite the high seroprevalence, most of the population had not been infected with SARS-CoV-2, highlighting the importance of continued measures to control viral spread and quick vaccine deployment to protect the vulnerable.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference36 articles.
1. AFP. WHO warns Africa is ill-equipped to deal with coronavirus due to ‘weaker health systems’. TheJournal.ie. https://www.thejournal.ie/world-health-organisation-african-coronavirus-5017867-Feb2020/ (2020).
2. Umviligihozo, G. et al. Sub-Saharan Africa preparedness and response to the COVID-19 pandemic: a perspective of early career African scientists. Wellcome Open Res. https://doi.org/10.12688/wellcomeopenres.16070.2 (2020).
3. Dong, E., Du, H. & Gardner, L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect. Dis. 20, 533–534 (2020).
4. Diop, B. Z., Ngom, M., Biyong, C. P. & Biyong, J. N. P. The relatively young and rural population may limit the spread and severity of COVID-19 in Africa: a modelling study. BMJ Glob. Health 5, e002699 (2020).
5. Stringhini, S. et al. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study. Lancet 396, 313–319 (2020).
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