Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus-Reference-Cited by-同舟云学术

Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus

Published:2020-07-09 Issue:1 Volume:11 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Guk Kyeonghye,Kim Hyeran,Lee Miyeon,Choi Yoon-Aa,Hwang Seul Gee,Han Gaon,Kim Hye-Nan,Kim Hongki,Park Hwangseo,Yong Dongeun,Kang Taejoon^ORCID,Lim Eun-Kyung,Jung Juyeon^ORCID

Abstract

AbstractThe emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant I223R/H275Y neuraminidase and prove the applicability of A4 antibody for direct detection of antiviral multidrug-resistant viruses in various sensing platforms, including naked-eye detection, surface-enhanced Raman scattering-based immunoassay, and lateral flow system. The development of the A4 antibody enables fast, simple, and reliable point-of-care assays of antiviral multidrug-resistant influenza viruses. In addition to current influenza virus infection testing methods that do not provide information on the antiviral drug-resistance of the virus, diagnostic tests for antiviral multidrug-resistant viruses will improve clinical judgment in the treatment of influenza virus infections, avoid the unnecessary prescription of ineffective drugs, and improve current therapies.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-020-17246-w.pdf

Reference43 articles.

1. Von Itzstein, M. et al. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363, 418–423 (1993).

2. Kim, C. U. et al. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J. Am. Chem. Soc. 119, 681–690 (1997).

3. Dawood, F. S., Jain, S., Fineli, L. & Shaw, M. W. Emergene of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med. 360, 2605–2615 (2009).

4. Kelly, H. & Cowling, B. J. Influenza: the rational use of oseltamivir. Lancet Infect. Dis. 385, 1700–1702 (2017).

5. Ward, P., Small, I., Smith, J., Suter, P. & Dutkowski, R. Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic. J. Antimicrob. Chemother. 55, 5–21 (2005).

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A new strategy based on a cascade amplification strategy biosensor for on-site eDNA detection and outbreak warning of crown-of-thorns starfish;Science of The Total Environment;2024-06

2. Hybrid CRISPR/Cas protein for one-pot detection of DNA and RNA;Biosensors and Bioelectronics;2023-01

3. SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus;Advanced Science;2022-10-18

4. Surface-enhanced Raman scattering-based immunoassay for severe acute respiratory syndrome coronavirus 2;Biosensors and Bioelectronics;2022-04

5. Silver Nanoparticles as Potent Multidrug-Resistant Incorporants in Biomedicine;Emerging Modalities in Mitigation of Antimicrobial Resistance;2022