Dysfunction of duplicated pair rice histone acetyltransferases causes segregation distortion and an interspecific reproductive barrier
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Published:2024-02-02
Issue:1
Volume:15
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Liao Ben, Xiang You-Huang, Li Yan, Yang Kai-Yang, Shan Jun-XiangORCID, Ye Wang-Wei, Dong Nai-QianORCID, Kan Yi, Yang Yi-Bing, Zhao Huai-Yu, Yu Hong-Xiao, Lu Zi-Qi, Zhao Yan, Zhao Qiang, Guo Dongling, Guo Shuang-Qin, Lei Jie-Jie, Mu Xiao-Rui, Cao Ying-Jie, Han BinORCID, Lin Hong-XuanORCID
Abstract
AbstractPostzygotic reproductive isolation, which results in the irreversible divergence of species, is commonly accompanied by hybrid sterility, necrosis/weakness, or lethality in the F1 or other offspring generations. Here we show that the loss of function of HWS1 and HWS2, a couple of duplicated paralogs, together confer complete interspecific incompatibility between Asian and African rice. Both of these non-Mendelian determinants encode the putative Esa1-associated factor 6 (EAF6) protein, which functions as a characteristic subunit of the histone H4 acetyltransferase complex regulating transcriptional activation via genome-wide histone modification. The proliferating tapetum and inappropriate polar nuclei arrangement cause defective pollen and seeds in F2 hybrid offspring due to the recombinant HWS1/2-mediated misregulation of vitamin (biotin and thiamine) metabolism and lipid synthesis. Evolutionary analysis of HWS1/2 suggests that this gene pair has undergone incomplete lineage sorting (ILS) and multiple gene duplication events during speciation. Our findings have not only uncovered a pair of speciation genes that control hybrid breakdown but also illustrate a passive mechanism that could be scaled up and used in the guidance and optimization of hybrid breeding applications for distant hybridization.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference77 articles.
1. Bomblies, K. Doomed lovers: mechanisms of isolation and incompatibility in plants. Annu Rev. Plant Biol. 61, 109–124 (2010). 2. Westram, A. M., Stankowski, S., Surendranadh, P. & Barton, N. What is reproductive isolation? J. Evol. Biol. 35, 1143–1164 (2022). 3. Chen, C. et al. A two-locus interaction causes interspecific hybrid weakness in rice. Nat. Commun. 5, 3357 (2014). 4. Chae, E. et al. Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis. Cell 159, 1341–1351 (2014). 5. Ichitani, K., Takemoto, Y., Iiyama, K., Taura, S. & Sato, M. Chromosomal location of HCA1 and HCA2, hybrid chlorosis genes in rice. Int. J. Plant Genomics 2012, 649081 (2012).
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